Article
Regulation by heat shock protein 27 of osteocalcin synthesis in osteoblasts.
Endocrinology - 1 May 2011
Kato Kenji, Adachi Seiji, Matsushima-Nishiwaki Rie, Minamitani Chiho, Natsume Hideo, Katagiri Yasuo, Hirose Yoshinobu, Mizutani Jun, Tokuda Haruhiko, Kozawa Osamu, Otsuka Takanobu
Abstract excerpt
We have previously reported that various stimuli, including sphingosine 1-phosphate, are able to induce heat shock protein (HSP) 27 in osteoblast-like MC3T3-E1 cells. However, the precise role of HSP27 in bone metabolism has not been satisfactory clarified. In this study, we investigated the effect of HSP27 on osteocalcin synthesis induced by bone morphogenetic protein (BMP)-4 or T₃ in these cells. In MC3T3-E1...
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