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Article

CREB-1 and AP-1 transcription factors JunD and Fra-2 regulate bone sialoprotein gene expression in human breast cancer cells.

Bone - 1 Feb 2008

Detry C, Lamour V, Castronovo V, Bellahcène A

Abstract excerpt

Bone sialoprotein (BSP) expression is detected in a variety of human osteotropic cancers. High expression of BSP in breast and prostate primary carcinomas is associated with progression and bone metastases development. In this study, we examined the transcriptional regulation of BSP gene expression in MDA-MB-231 and MCF-7 human breast cancer cells compared with Saos-2 human osteoblast-like cells. BSP human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP Response Element-Binding Protein

Share to Gene Expression Regulation, Neoplastic

Share to Proto-Oncogene Proteins c-jun

Share to RNA, Small Interfering

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Source

Identifiers

PMID: 18088579
DOI: 10.1016/j.bone.2007.10.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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