Article
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.
Cell - 29 Oct 2010
Law Martin J, Lower Karen M, Voon Hsiao P J, Hughes Jim R, Garrick David, Viprakasit Vip, Mitson Matthew, De Gobbi Marco, Marra Marco, Morris Andrew, Abbott Aaron, Wilder Steven P, Taylor Stephen, Santos Guilherme M, Cross Joe, Ayyub Helena, Jones Steven, Ragoussis Jiannis, Rhodes Daniela, Dunham Ian, Higgs Douglas R, Gibbons Richard J
Abstract excerpt
ATRX is an X-linked gene of the SWI/SNF family, mutations in which cause syndromal mental retardation and downregulation of α-globin expression. Here we show that ATRX binds to tandem repeat (TR) sequences in both telomeres and euchromatin. Genes associated with these TRs can be dysregulated when ATRX is mutated, and the change in expression is determined by the size of the TR, producing skewed allelic...
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