Article
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.
PLoS genetics - 1 Apr 2006
Garrick David, Sharpe Jackie A, Arkell Ruth, Dobbie Lorraine, Smith Andrew J H, Wood William G, Higgs Douglas R, Gibbons Richard J
Abstract excerpt
ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci. Mutations in ATRX provided the first example of a human genetic disease associated with defects in such proteins. To better understand the role of ATRX in development and the associated abnormalities in the ATR-X (alpha thalassemia mental retardation, X-linked)...
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