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Phenotypic screening of phylomer peptide libraries derived from genome fragments to identify and validate new targets and therapeutics.

Future medicinal chemistry - 1 May 2009

Watt Paul M

Abstract excerpt

BACKGROUND: Phenotypic screening of random peptide libraries has been hampered by very poor hit rates. This is probably due to the fact that random combinatorial peptide libraries contain an insufficiently large proportion of secondary and/or tertiary structures that are likely to interact in a stable manner with multiple classes of potential target proteins. Phylomer libraries, by contrast, are derived from...

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PMID: 21425969
DOI: 10.4155/fmc.09.28

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