Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional polymorphism at 3'UTR of the PAX6 gene may confer risk for extreme myopia in the Chinese.

Investigative ophthalmology & visual science - 1 Jun 2011

Liang Chung-Ling, Hsi Edward, Chen Ku-Chung, Pan Yun-Ru, Wang Yung-Song, Juo Suh-Hang Hank

Abstract excerpt

PURPOSE: The paired box 6 (PAX6) is involved in eye development and associated with several ocular diseases. Conflicting results have been reported regarding the association between PAX6 polymorphism and myopia. This case-control study and functional assay were conducted to identified a functional risk polymorphism for myopia. METHODS: The study cohort included 1083 cases (≤ -6.0 D) and 1096 controls (≥ -1.5 D)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Eye Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Myopia, Degenerative

Share to Paired Box Transcription Factors

Share to PAX6 Transcription Factor

Share to Repressor Proteins

Share to Taiwan

Source

Identifiers

PMID: 21421876
DOI: 10.1167/iovs.10-5859

Genes

PAX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional polymorphism at 3'UTR of the PAX6 gene may confer risk for extreme myopia in the Chinese.PMID 21421876Read ↗

Association of paired box 6 with high myopia in Japanese.Semantic proximity Read ↗

A PAX6 gene polymorphism is associated with genetic predisposition to extreme myopia.Semantic proximity Read ↗

PAX6 gene associated with high myopia: a meta-analysis.Semantic proximity Read ↗

PAX6 haplotypes are associated with high myopia in Han chinese.Semantic proximity Read ↗

Association of the PAX6 gene with extreme myopia rather than lower grade myopias.Semantic proximity Read ↗

Association of PAX6 polymorphisms with high myopia in Han Chinese nuclear families.Semantic proximity Read ↗

The Systemic Genotype-Phenotype Characterization of PAX6-Related Eye Disease in 164 Chinese Families.Semantic proximity Read ↗

A functional polymorphism at the FGF10 gene is associated with extreme myopia.Semantic proximity Read ↗

A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins.Semantic proximity Read ↗

Mutation Screening of ARR3, CACNA1F, P4HA2, TRPM1, COL2A1, COL11A1 and PAX6 in a Chinese Cohort of 37 Patients with Early-Onset High Myopia.Semantic proximity Read ↗

Identification of a Novel Frameshift Variant of ARR3 Related to X-Linked Female-Limited Early-Onset High Myopia and Study on the Effect of X Chromosome Inactivation on the Myopia SeveritySemantic proximity Read ↗

A novel de novo duplication mutation of PAX6 in a Chinese family with aniridia and other ocular abnormalities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.