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Article

Gain-of-function polymorphisms of cystathionine β-synthase and delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage.

Journal of neurosurgery - 1 Jul 2011

Grobelny Bartosz T, Ducruet Andrew F, DeRosa Peter A, Kotchetkov Ivan S, Zacharia Brad E, Hickman Zachary L, Fernandez Luis, Narula Reshma, Claassen Jan, Lee Kiwon, Badjatia Neeraj, Mayer Stephan A, Connolly E Sander

Abstract excerpt

OBJECT: Cystathionine β-synthase (CBS) is an enzyme that metabolizes homocysteine to form H(2)S in the brain. Hydrogen sulfide functions as a vasodilator as well as a regulator of neuronal ion channels and multiple intracellular signaling pathways. Given the myriad effects of H(2)S, the authors hypothesized that patients possessing gain-of-function polymorphisms of the CBS gene will experience a decreased...

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Identifiers

PMID: 21417705
DOI: 10.3171/2011.2.JNS101414

Genes

CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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