Article
Modulation of the photocycle of a LOV domain photoreceptor by the hydrogen-bonding network.
Journal of the American Chemical Society - 13 Apr 2011
Raffelberg Sarah, Mansurova Madina, Gärtner Wolfgang, Losi Aba
Abstract excerpt
An extended hydrogen-bonding (HB) network stabilizes the isoalloxazine ring of the flavin mononucleotide (FMN) chromophore within the photosensing LOV domain of blue-light protein receptors, via interactions between the C(2)═O, N(3)H, C(4)═O, and N(5) groups and conserved glutamine and asparagine residues. In this work we studied the influence of the HB network on the efficiency, kinetics, and energetics of a LOV...
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