Article
Regulation and role of an RNA-binding protein Msa2 in controlling the sexual differentiation of fission yeast.
Current genetics - 1 Jun 2011
Oowatari Yasuo, Jeong Heetae, Tanae Katsuhiro, Nakagawa Tsuyoshi, Kawamukai Makoto
Abstract excerpt
The msa2/nrd1 gene encodes an RNA-binding protein that negatively regulates sexual differentiation of fission yeast Schizosaccharomyces pombe by repressing the Ste11-regulated genes. However, it is not known how Msa2 regulates sexual differentiation, and to characterize its role, we altered the msa2 gene by inducing point mutations and tested the resulting mutants for their ability to inhibit sexual...
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