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Article

Human autoantibodies against the 70-kd polypeptide of U1 small nuclear RNP are associated with HLA-DR4 among connective tissue disease patients.

Arthritis and rheumatism - 1 May 1990

Hoffman R W, Rettenmaier L J, Takeda Y, Hewett J E, Pettersson I, Nyman U, Luger A M, Sharp G C

Abstract excerpt

Serum samples from patients with connective tissue disease (CTD) were characterized using a recently developed enzyme-linked immunosorbent assay for reactivity with individual specific polypeptides of U1 small nuclear ribonucleoproteins, including the U1-70-kd protein. The distribution of HLA antigens was compared in CTD patients with and in those without anti-U1-70-kd autoantibodies and in normal controls. The...

Topics

Antibodies, Antinuclear
Autoantibodies
Connective Tissue Diseases
Enzyme-Linked Immunosorbent Assay
Female
HLA-DQ Antigens
HLA-DR Antigens
HLA-DR4 Antigen
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Ribonucleoproteins

Ribonucleoproteins, Small Nuclear

Source

Identifiers

PMID: 2140681
DOI: 10.1002/art.1780330509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2140681-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Human autoantibodies against the 70-kd polypeptide of U1 small nuclear RNP are associated with HLA-DR4 among connective tissue disease patients.PMID 2140681Read ↗

HLA-DPB1*0401 is associated with the presence of autoantibodies reactive with the U1-70 kD polypeptide antigen of U1-small nuclear ribonucleoprotein among connective tissue disease patients.Semantic proximity Read ↗

Molecular genetic analysis of HLA-DR and HLA-DQ genes among anti-U1-70-kd autoantibody positive connective tissue disease patients.Semantic proximity Read ↗

Major histocompatibility complex class II gene associations with anti-U1 small nuclear ribonucleoprotein antibody. Relationship to immunoreactivity with individual constituent proteins.Semantic proximity Read ↗

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