Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CMX001 (1- O -Hexadecyloxypropyl-Cidofovir) Inhibits Polyomavirus JC Replication in Human Brain Progenitor-Derived Astrocytes

15 Mar 2011

Abstract excerpt

Polyomavirus JC (JCV) replication causes progressive multifocal leukoencephalopathy (PML), a frequently fatal brain disease in immunodeficient patients, yet antiviral drugs are lacking. We characterized the lipid conjugate 1-O-hexadecyloxypropyl-cidofovir (CMX001) regarding JCV (Mad-4) replication in human brain progenitor-derived astrocytes (PDA) and the simian virus 40 (SV40) large-T-antigen-expressing COS-7...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Full-Duplex Wireless Communications
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21402853
DOI: 10.1128/aac.00046-11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CMX001 (1- O -Hexadecyloxypropyl-Cidofovir) Inhibits Polyomavirus JC Replication in Human Brain Progenitor-Derived AstrocytesPMID 21402853Read ↗

Antiviral Effects of Artesunate on JC Polyomavirus Replication in COS-7 CellsSemantic proximity Read ↗

1- <i>O</i> -Hexadecyloxypropyl Cidofovir (CMX001) Effectively Inhibits Polyomavirus BK Replication in Primary Human Renal Tubular Epithelial CellsSemantic proximity Read ↗

The human JC polyomavirus (JCPyV): virological background and clinical implications.Semantic proximity Read ↗

JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence.Semantic proximity Read ↗

Biogenesis of JC polyomavirus associated extracellular vesiclesSemantic proximity Read ↗

Polyomavirus JC in the context of immunosuppression: a series of adaptive, DNA replication-driven recombination events in the development of progressive multifocal leukoencephalopathy.Semantic proximity Read ↗

Human demyelinating disease and the polyomavirus JCVSemantic proximity Read ↗

Comparison of qPCR with ddPCR for the Quantification of JC Polyomavirus in CSF from Patients with Progressive Multifocal LeukoencephalopathySemantic proximity Read ↗

[New trends in progressive multifocal leukoencephalopathy].Semantic proximity Read ↗

Rearranged JC Virus Noncoding Control Regions Found in Progressive Multifocal Leukoencephalopathy Patient Samples Increase Virus Early Gene Expression and Replication RateSemantic proximity Read ↗

Detection of JC virus DNA in peripheral lymphocytes from patients with and without progressive multifocal leukoencephalopathySemantic proximity Read ↗

Inhibitory effect of serotonin antagonists on JC virus propagation in a carrier culture of human neuroblastoma cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.