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Human Mesenchymal Stem Cells Are Susceptible to Lysis by CD8 <sup>+</sup> T Cells and NK Cells

1 Nov 2011

Abstract excerpt

There is growing interest in the use of mesenchymal stem cells (MSCs) to improve the outcome of organ transplantation. The immunogenicity of MSCs is, however, unclear and is important for the efficacy of MSC therapy and for potential sensitization against donor antigens. We investigated the susceptibility of autologous and allogeneic MSCs for lysis by CD8(+) T-lymphocytes and NK cells in a kidney transplant...

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PMID: 21396164
DOI: 10.3727/096368910x564076

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