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Article

A midzone-based ruler adjusts chromosome compaction to anaphase spindle length.

Science (New York, N.Y.) - 22 Apr 2011

Neurohr Gabriel, Naegeli Andreas, Titos Iris, Theler Dominik, Greber Basil, Díez Javier, Gabaldón Toni, Mendoza Manuel, Barral Yves

Abstract excerpt

Partitioning of chromatids during mitosis requires that chromosome compaction and spindle length scale appropriately with each other. However, it is not clear whether chromosome condensation and spindle elongation are linked. Here, we find that yeast cells could cope with a 45% increase in the length of their longest chromosome arm by increasing its condensation. The spindle midzone, aurora/Ipl1 activity, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21393511
DOI: 10.1126/science.1201578

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