Article
An alternative first exon in the distal end of the erythroid ankyrin gene leads to production of a small isoform containing an NH2-terminal membrane anchor.
Genomics - 15 May 1998
Birkenmeier C S, Sharp J J, Gifford E J, Deveau S A, Barker J E
Abstract excerpt
Mouse erythroid ankyrin is encoded by the Ank1 gene on Chromosome 8. The best studied isoform is 210 kDa and contains three large functional domains. We have recently reported a small Ank1 isoform (relative mobility 25 kDa) that localizes to the M and Z lines in skeletal muscle. Analyses of cDNA...
Topics
- Alleles
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Ankyrins
- Base Sequence
- Cloning, Molecular
- DNA, Complementary
- Erythrocyte Membrane
- Exons
- Immunoblotting
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Muscle, Skeletal
- Organ Specificity
- Peptide Fragments
- Promoter Regions, Genetic