Article
Hereditary spherocytosis in zebrafishrieslingillustrates evolution of erythroid β-spectrin structure, and function in red cell morphogenesis and membrane stability
1 Dec 2000
Abstract excerpt
Spectrins are key cytoskeleton proteins with roles in membrane integrity, cell morphology, organelle transport and cell polarity of varied cell types during development. Defects in erythroid spectrins in humans result in congenital hemolytic anemias with altered red cell morphology. Although well characterized in mammals and invertebrates, analysis of the structure and function of non-mammalian vertebrate...
