Article
Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a.
Molecular and cellular biology - 1 Apr 1990
Kaddurah-Daouk R, Lillie J W, Daouk G H, Green M R, Kingston R, Schimmel P
Abstract excerpt
Brain creatine kinase is a major enzyme of cellular energy metabolism. It is overexpressed in a wide range of tumor cell lines and is used as a tumor marker. We reported recently that the promoter of the human gene has a strong sequence similarity to the adenovirus E2E promoter. This similarity suggested that the brain creatine kinase gene may be regulated by the viral activator E1a. Experiments reported here...
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