Article
Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a.
Molecular and cellular biology - 1 Apr 1990
Kaddurah-Daouk R, Lillie J W, Daouk G H, Green M R, Kingston R, Schimmel P
Abstract excerpt
Brain creatine kinase is a major enzyme of cellular energy metabolism. It is overexpressed in a wide range of tumor cell lines and is used as a tumor marker. We reported recently that the promoter of the human gene has a strong sequence similarity to the adenovirus E2E promoter. This similarity s...
Topics
- Adenovirus Early Proteins
- Adenoviruses, Human
- Cell Transformation, Viral
- Chromosome Deletion
- Creatine Kinase
- DNA-Binding Proteins
- Energy Metabolism
- Enzyme Induction
- HeLa Cells
- Humans
- Isoenzymes
- Kinetics
- Mutation
- Oncogene Proteins, Viral
- Restriction Mapping
- Transfection