Article
Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain.
BMC microbiology - 8 Mar 2011
Lin Yi-Chun, Lu Min-Chi, Tang Hui-Ling, Liu Hsu-Chung, Chen Ching-Hsien, Liu Keh-Sen, Lin Chingju, Chiou Chien-Shun, Chiang Ming-Ko, Chen Chuan-Mu, Lai Yi-Chyi
Abstract excerpt
BACKGROUND: Klebsiella pneumoniae displaying the hypermucoviscosity (HV) phenotype are considered more virulent than HV-negative strains. Nevertheless, the emergence of tissue-abscesses-associated HV-negative isolates motivated us to re-evaluate the role of HV-phenotype. RESULTS: Instead of genetically manipulating the HV-phenotype of K. pneumoniae, we selected two clinically isolated K1 strains, 1112...
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