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Article

The estimation of selection coefficients in Afrikaners: Huntington disease, porphyria variegata, and lipoid proteinosis.

American journal of human genetics - 1 Mar 1990

Stine O C, Smith K D

Abstract excerpt

The effects of mutation, migration, random drift, and selection on the change in frequency of the alleles associated with Huntington disease, porphyria variegata, and lipoid proteinosis have been assessed in the Afrikaner population of South Africa. Although admixture cannot be completely discoun...

Topics

Ethnicity
Gene Frequency
Genes, Dominant
Humans
Huntington Disease
Lipidoses
Lipoid Proteinosis of Urbach and Wiethe
Liver Diseases
Mutation
Netherlands
Porphyrias
Selection, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

South Africa

White People

Source

Open in PubMed Open full text

Identifiers

PMID: 2137963
PMCID: PMC1683615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2137963-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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