Article
Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development.
PLoS genetics - 1 Feb 2011
Sovio Ulla, Mook-Kanamori Dennis O, Warrington Nicole M, Lawrence Robert, Briollais Laurent, Palmer Colin N A, Cecil Joanne, Sandling Johanna K, Syvänen Ann-Christine, Kaakinen Marika, Beilin Lawrie J, Millwood Iona Y, Bennett Amanda J, Laitinen Jaana, Pouta Anneli, Molitor John, Davey Smith George, Ben-Shlomo Yoav, Jaddoe Vincent W V, Palmer Lyle J, Pennell Craig E, Cole Tim J, McCarthy Mark I, Järvelin Marjo-Riitta, Timpson Nicholas J
Abstract excerpt
An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We meta-analyzed associations between the FTO locus (rs9939609) and BMI in samples, aged from early infancy to 13 years, from 8 cohorts of European ancestry. We found a positive association between additional minor (A) alleles and BMI from 5.5 years onwards, but an inverse association below age 2.5 years....
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