Article
A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos.
Molecular microbiology - 1 May 2011
Alibaud Laeticia, Rombouts Yoann, Trivelli Xavier, Burguière Adeline, Cirillo Suat L G, Cirillo Jeffrey D, Dubremetz Jean-François, Guérardel Yann, Lutfalla Georges, Kremer Laurent
Abstract excerpt
Infection of the zebrafish with Mycobacterium marinum is regarded as a well-established experimental model to study the pathogenicity of Mycobacterium tuberculosis. Herein, a M. marinum transposon mutant library was screened for attenuated M. marinum phenotypes using a Dictyostelium discoideum assay. In one attenuated mutant, the transposon was located within tesA, encoding a putative type II thioesterase....
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