Article
Extracellular YB-1 blockade in experimental nephritis upregulates Notch-3 receptor expression and signaling.
Nephron. Experimental nephrology - 1 Jan 2011
Raffetseder Ute, Rauen Thomas, Boor Peter, Ostendorf Tammo, Hanssen Lydia, Floege Jürgen, En-Nia Abdelaziz, Djudjaj Sonja, Frye Björn C, Mertens Peter R
Abstract excerpt
BACKGROUND: Notch receptors are involved in kidney development and pathogenesis of inflammatory glomerular diseases. Given the secretion of Y-box (YB) protein-1 following cytokine stimulation and subsequent extracellular association with membrane receptor Notch-3 in vitro, we elucidated functional effects of YB-1 targeting on the Notch-3 signaling pathway. METHODS: Rat mesangial cells were challenged with a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.