Article
Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component.
Disease models & mechanisms - 1 Jul 2011
Stoop Esther J M, Schipper Tim, Rosendahl Huber Sietske K, Nezhinsky Alexander E, Verbeek Fons J, Gurcha Sudagar S, Besra Gurdyal S, Vandenbroucke-Grauls Christina M J E, Bitter Wilbert, van der Sar Astrid M
Abstract excerpt
The hallmark of tuberculosis (TB) is the formation of granulomas, which are clusters of infected macrophages surrounded by additional macrophages, neutrophils and lymphocytes. Although it has long been thought that granulomas are beneficial for the host, there is evidence that mycobacteria also promote the formation of these structures. In this study, we aimed to identify new mycobacterial factors involved in the...
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