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Article

TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.

Nature communications - 2 Sept 2014

Lindy Amanda S, Parekh Puja K, Zhu Richard, Kanju Patrick, Chintapalli Sree V, Tsvilovskyy Volodymyr, Patterson Randen L, Anishkin Andriy, van Rossum Damian B, Liedtke Wolfgang B

Abstract excerpt

Animals need to sense and react to potentially dangerous environments. TRP ion channels participate in nociception, presumably via Ca(2+) influx, in most animal species. However, the relationship between ion permeation and animals' nocifensive behaviour is unknown. Here we use an invertebrate animal model with relevance for mammalian pain. We analyse the putative selectivity filter of OSM-9, a TRPV channel, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25178952
DOI: 10.1038/ncomms5734
PMCID: PMC4164786

Genes

OSM

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