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Second-Site Compensatory Mutations of HIV-1 Capsid Mutations

4 Mar 2011

Abstract excerpt

The human immunodeficiency virus (HIV) capsid (CA) protein assembles into a hexameric lattice that forms the mature virus core. Contacts between the CA N-terminal domain (NTD) of one monomer and the C-terminal domain (CTD) of the adjacent monomer are important for the assembly of this core. In this study, we have examined the effects of mutations in the NTD region associated with this interaction. We have found...

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PMID: 21367891
DOI: 10.1128/jvi.00099-11

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