Article
Prognostic significance of immunophenotypic and karyotypic features of Philadelphia positive B-lymphoblastic leukemia in the era of tyrosine kinase inhibitors.
Cancer - 1 Sept 2011
Jaso Jesse, Thomas Deborah A, Cunningham Krista, Jorgensen Jeffrey L, Kantarjian Hagop M, Medeiros L Jeffrey, Wang Sa A
Abstract excerpt
BACKGROUND: Philadelphia chromosome (Ph)-positive B-lymphoblastic leukemia exhibits immunophenotypic, karyotypic, and molecular genetic heterogeneity. The prognostic significance of these parameters was assessed in the context of intensive tyrosine kinase inhibitor (TKI)-based chemotherapy. METHODS: The authors studied 65 adult patients with Ph-positive acute lymphoblastic leukemia (ALL) who received treatment...
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