Beyond thriftiness: independent and interactive effects of genetic and dietary factors on variations in fat deposition and distribution across populations.

Abstract excerpt

The thrifty genotype hypothesis initiated speculation that feast and famine cycling throughout history may have led to group-specific alterations of the human genome, thereby augmenting the capacity for excessive fat mass accrual when immersed in the modern-day obesogenic environment. Contemporary work, however, suggests alternative mechanisms influencing fuel utilization and subsequent tissue partitioning to be...

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