Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Natural selection and human adiposity: crafty genotype, thrifty phenotype.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 11 Sept 2023

Wells Jonathan C K

Abstract excerpt

Evolutionary perspectives on obesity have aimed to understand how the genetic constitution of individuals has been shaped by selective pressures such as famine, predation or infectious disease. The dual intervention model assumes strong selection on lower and upper limits of adiposity, but negligible fitness implications for intermediate adiposity. These frameworks are agnostic to age, sex and condition. I argue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Adiposity
Share to Birth, Development, and Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet and metabolism studies

Share to Genotype

Share to Obesity

Share to Phenotype

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 37482776
DOI: 10.1098/rstb.2022.0224
PMCID: PMC10363707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Natural selection and human adiposity: crafty genotype, thrifty phenotype.PMID 37482776Read ↗

Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms.Semantic proximity Read ↗

The evolution of human fatness and susceptibility to obesity: an ethological approach.Semantic proximity Read ↗

The evolution of human adiposity and obesity: where did it all go wrong?Semantic proximity Read ↗

The evolution of body fatness: trading off disease and predation riskSemantic proximity Read ↗

A nonadaptive scenario explaining the genetic predisposition to obesity: the "predation release" hypothesis.Semantic proximity Read ↗

Human obesity: an evolutionary approach to understanding our bulging waistlineSemantic proximity Read ↗

On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations.Semantic proximity Read ↗

On the evolutionary origins of obesity: a new hypothesis.Semantic proximity Read ↗

Body composition and susceptibility to type 2 diabetes: an evolutionary perspective.Semantic proximity Read ↗

Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies.Semantic proximity Read ↗

Integrating the Thrifty Genotype and Evolutionary Mismatch Hypotheses to understand variation in cardiometabolic disease riskSemantic proximity Read ↗

Human adaptation response to obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.