Article
The adult mouse and human pancreas contain rare multipotent stem cells that express insulin.
Cell stem cell - 4 Mar 2011
Smukler Simon R, Arntfield Margot E, Razavi Rozita, Bikopoulos George, Karpowicz Phillip, Seaberg Raewyn, Dai Feihan, Lee Simon, Ahrens Rosemary, Fraser Paul E, Wheeler Michael B, van der Kooy Derek
Abstract excerpt
The search for putative precursor cells within the pancreas has been the focus of extensive research. Previously, we identified rare pancreas-derived multipotent precursor (PMP) cells in the mouse with the intriguing capacity to generate progeny in the pancreatic and neural lineages. Here, we establish the embryonic pancreas as the developmental source of PMPs through lineage-labeling experiments. We also show...
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