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Article

Modification of the sugar specificity of a plant lectin: structural studies on a point mutant of Erythrina corallodendron lectin.

Acta crystallographica. Section D, Biological crystallography - 1 Mar 2011

Thamotharan Subbiah, Karthikeyan Tangavelou, Kulkarni Kiran A, Shetty Kartika N, Surolia Avadhesha, Vijayan Mamannamana, Suguna Kaza

Abstract excerpt

A mutant of Erythrina corallodendron lectin was generated with the aim of enhancing its affinity for N-acetylgalactosamine. A tyrosine residue close to the binding site of the lectin was mutated to a glycine in order to facilitate stronger interactions between the acetamido group of the sugar and the lectin which were prevented by the side chain of the tyrosine in the wild-type lectin. The crystal structures of...

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Identifiers

PMID: 21358053
DOI: 10.1107/S0907444911004525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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