Article
Distinct germ line polymorphisms underlie glioma morphologic heterogeneity.
Cancer genetics - 1 Jan 2011
Jenkins Robert B, Wrensch Margaret R, Johnson Derek, Fridley Brooke L, Decker Paul A, Xiao Yuanyuan, Kollmeyer Thomas M, Rynearson Amanda L, Fink Stephanie, Rice Terri, McCoy Lucie S, Halder Chandralekha, Kosel Matthew L, Giannini Caterina, Tihan Tarik, O'Neill Brian P, Lachance Daniel H, Yang Ping, Wiemels Joseph, Wiencke John K
Abstract excerpt
Two recent genome-wide association studies reported that single nucleotide polymorphisms (SNPs) in (or near) TERT (5p15), CCDC26 (8q24), CDKN2A/B (9p21), PHLDB1 (11q23), and RTEL1 (20q13) are associated with infiltrating glioma. From these reports, it was not clear whether the single nucleotide polymorphism associations predispose to glioma in general or whether they are specific to certain glioma grades or...
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