Article
Epigenetic reprogramming in the porcine germ line.
BMC developmental biology - 25 Feb 2011
Hyldig Sara M W, Croxall Nicola, Contreras David A, Thomsen Preben D, Alberio Ramiro
Abstract excerpt
BACKGROUND: Epigenetic reprogramming is critical for genome regulation during germ line development. Genome-wide demethylation in mouse primordial germ cells (PGC) is a unique reprogramming event essential for erasing epigenetic memory and preventing the transmission of epimutations to the next generation. In addition to DNA demethylation, PGC are subject to a major reprogramming of histone marks, and many of...
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