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Article

Depletion of the human N<sup>α</sup>‐terminal acetyltransferase A induces p53‐dependent apoptosis and p53‐independent growth inhibition

22 Feb 2010

Abstract excerpt

The human protein N(α)-terminal acetyltransferase A complex (hNatA), composed of the catalytic hNaa10p (hArd1) and auxiliary hNaa15p (hNat1/NATH/Tubedown) subunits, was reported to be important for cell survival and growth of various types of cancer. However, little is known about the mechanisms mediating growth inhibition and apoptosis following loss of hNatA function. Here, we have screened 11 different thyroid...

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PMID: 21351257
DOI: 10.1002/ijc.25275

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