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Article

Investigation of interferon-α response by a single amino acid substitution of nonstructural protein 5A in hepatitis C virus-infected patients.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Aug 2011

Noguchi Tohru, Tamori Akihiro, Ogura Naoki, Hori Yuji, Ikeda Satoru, Nishiguchi Shuhei

Abstract excerpt

The therapeutic efficacy of interferon (IFN) for the hepatitis C is closely related with mutations in interferon sensitivity determining region or V3 domain of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A). However, the relationship between alanine aminotransferase (ALT) normalization and the NS5A variability remains unclear. To clarify these features of NS5A, we examined the genetic variability of...

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Identifiers

PMID: 21348779
DOI: 10.1089/jir.2010.0128

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