Article
The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women.
PloS one - 8 Feb 2011
Lurie Galina, Gaudet Mia M, Spurdle Amanda B, Carney Michael E, Wilkens Lynne R, Yang Hannah P, Weiss Noel S, Webb Penelope M, Thompson Pamela J, Terada Keith, Setiawan Veronica Wendy, Rebbeck Timothy R, Prescott Jennifer, Orlow Irene, O'Mara Tracy, Olson Sara H, Narod Steven A, Matsuno Rayna K, Lissowska Jolanta, Liang Xiaolin, Levine Douglas A, Le Marchand Loic, Kolonel Laurence N, Henderson Brian E, Garcia-Closas Montserrat, Doherty Jennifer Anne, De Vivo Immaculata, Chen Chu, Brinton Louise A, Akbari Mohammad R, Goodman Marc T
Abstract excerpt
Overweight and obesity are strongly associated with endometrial cancer. Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity. We examined the association of FTO rs9939609 and MC4R rs17782313 with endometrial cancer risk in a pooled analysis of nine case-control studies within the...