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Article

Heterogeneity of hemoglobin H disease in childhood.

The New England journal of medicine - 24 Feb 2011

Lal Ashutosh, Goldrich Michael L, Haines Drucilla A, Azimi Mahin, Singer Sylvia T, Vichinsky Elliott P

Abstract excerpt

BACKGROUND: Early diagnosis during newborn screening or infancy has enabled the observation of the natural history of hemoglobin H disease, a subtype of α-thalassemia. METHODS: We analyzed longitudinal clinical data for patients with hemoglobin H disease arising from the deletion of three of four α-globin genes (HbH) and from hemoglobin H Constant Spring (HCS), caused by the deletion of two α-globin genes and the...

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Identifiers

PMID: 21345100
DOI: 10.1056/NEJMoa1010174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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