Article
Strobe sequence design for haplotype assembly.
BMC bioinformatics - 15 Feb 2011
Lo Christine, Bashir Ali, Bansal Vikas, Bafna Vineet
Abstract excerpt
BACKGROUND: Humans are diploid, carrying two copies of each chromosome, one from each parent. Separating the paternal and maternal chromosomes is an important component of genetic analyses such as determining genetic association, inferring evolutionary scenarios, computing recombination rates, and detecting cis-regulatory events. As the pair of chromosomes are mostly identical to each other, linking together of...
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