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Article

A rapid molecular approach for chromosomal phasing.

PloS one - 1 Jan 2015

Regan John F, Kamitaki Nolan, Legler Tina, Cooper Samantha, Klitgord Niels, Karlin-Neumann George, Wong Catherine, Hodges Shawn, Koehler Ryan, Tzonev Svilen, McCarroll Steven A

Abstract excerpt

Determining the chromosomal phase of pairs of sequence variants - the arrangement of specific alleles as haplotypes - is a routine challenge in molecular genetics. Here we describe Drop-Phase, a molecular method for quickly ascertaining the phase of pairs of DNA sequence variants (separated by 1-200 kb) without cloning or manual single-molecule dilution. In each Drop-Phase reaction, genomic DNA segments are...

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PMID: 25739099
DOI: 10.1371/journal.pone.0118270
PMCID: PMC4349636

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CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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