Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tankyrase Inhibition Attenuates Cardiac Dilatation and Dysfunction in Ischemic Heart Failure

2 Sept 2022

Abstract excerpt

Hyperactive poly(ADP-ribose) polymerases (PARP) promote ischemic heart failure (IHF) after myocardial infarction (MI). However, the role of tankyrases (TNKSs), members of the PARP family, in pathogenesis of IHF remains unknown. We investigated the expression and activation of TNKSs in myocardium of IHF patients and MI rats. We explored the cardioprotective effect of TNKS inhibition in an isoproterenol-induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Fibrosis and Remodeling
Share to Signaling Pathways in Disease
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36077457
DOI: 10.3390/ijms231710059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tankyrase Inhibition Attenuates Cardiac Dilatation and Dysfunction in Ischemic Heart FailurePMID 36077457Read ↗

Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitorsSemantic proximity Read ↗

KAT2A-targeted inhibition prevents an inflammatory response to protect the myocardiumSemantic proximity Read ↗

ZNFX1 suppresses apoptosis-associated mRNA stability in cardiomyocyte to protect against myocardial infarctionSemantic proximity Read ↗

FoxO, Autophagy, and Cardiac RemodelingSemantic proximity Read ↗

ALKBH5 mediated RNA N6-methyladenosine demethylation protects against myocardial I/R induced injury via FSP1 dependent inhibition of ferroptosisSemantic proximity Read ↗

LRRK2 Deficiency Protects Hearts from Myocardial Infarction Injury in Mice via the P53/HMGB1 PathwaySemantic proximity Read ↗

Wnt Signaling Inhibitors as Therapeutic Approach in Ischemic Heart DiseaseSemantic proximity Read ↗

RNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative SplicingSemantic proximity Read ↗

LncRNA ZFAS1 as a SERCA2a Inhibitor to Cause Intracellular Ca2+ Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction.Semantic proximity Read ↗

Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failureSemantic proximity Read ↗

DNMT1 methylation of LncRNA-ANRIL causes myocardial fibrosis pyroptosis by interfering with the NLRP3/Caspase-1 pathwaySemantic proximity Read ↗

m6A demethylase ALKBH5 attenuates doxorubicin-induced cardiotoxicity via posttranscriptional stabilization of Rasal3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.