Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A family study of HbS in a Malay family by molecular analysis.

The Malaysian journal of pathology - 1 Dec 2010

Hafiza Alauddin, Noor Hamidah Hussin, Noor Farisah A Razak, Azlin Ithnin, Ainoon Othman

Abstract excerpt

Sickle cell disease (SCD) is an inherited red cell disorder, characterized by the tendency of haemoglobin S or sickle haemoglobin to polymerize and assume a characteristic sickle shape. Molecular analysis has been the mainstay of detection method when confirmation is required. Previously a polymerase chain reaction (PCR)-based restriction enzyme analysis was used for this purpose. A simple bidirectional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fathers
Share to Homozygote
Share to Malaysia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemoglobin, Sickle

Share to Heterozygote

Share to Anemia, Sickle Cell

Share to Nucleic Acid Amplification Techniques

Share to Siblings

Source

Identifiers

PMID: 21329186

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A family study of HbS in a Malay family by molecular analysis.PMID 21329186Read ↗

Detection of beta-globin gene mutations among Kelantan Malay thalassaemia patients by polymerase chain reaction restriction fragment length polymorphism.Semantic proximity Read ↗

Molecular analysis of Iranian families with sickle cell disease.Semantic proximity Read ↗

Characterization of Hemoglobin Malay Phenotypes in Tertiary Hospitals.Semantic proximity Read ↗

Characterisation and confirmation of rare beta-thalassaemia mutations in the Malay, Chinese and Indian ethnic groups in Malaysia.Semantic proximity Read ↗

Hb E beta +-thalassaemia in west Malaysia: clinical features in the most common beta-thalassaemia mutation of the Malays [IVS 1-5 (G-->C)].Semantic proximity Read ↗

Specific and straightforward molecular investigation of β-thalassemia mutations in the Malaysian Malays and Chinese using direct TaqMan genotyping assays.Semantic proximity Read ↗

A large beta-thalassemia deletion in a family of Indonesian-Malay descent.Semantic proximity Read ↗

A portable molecular laboratory for rapid genotyping in the field: application to sickle cell diseaseSemantic proximity Read ↗

First case of Hb Fontainebleau with sickle haemoglobin and other non-deletional α gene variants identified in neonates during newborn screening for sickle cell disorders.Semantic proximity Read ↗

The use of Taqman genotyping assays for rapid confirmation of β-thalassaemia mutations in the Malays: accurate diagnosis with low DNA concentrations.Semantic proximity Read ↗

beta-thalassemia intermedia caused by compound heterozygosity for Hb Malay (beta codon 19 AAC-->AGC; asn-->Ser) and codons 41/42 (-CTTT) beta(0)-thalassemia mutation.Semantic proximity Read ↗

Hb lepore/β0-thalassaemia with α+-thalassaemia interactions, a potential diagnostic pitfall.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.