Article
Detection of beta-globin gene mutations among Kelantan Malay thalassaemia patients by polymerase chain reaction restriction fragment length polymorphism.
Singapore medical journal - 1 Dec 2008
Rozitah R, Nizam M Z, Nur Shafawati A R, Nor Atifah M A, Dewi M, Kannan T P, Ariffin N, Norsarwany M, Setianingsih I, Harahap A, Zilfalil B A
Abstract excerpt
INTRODUCTION: Beta-thalassaemia major is an autosomal recessive disorder that results in severe microcytic, hypochromic, haemolytic anaemia among affected patients. Beta-thalassaemia has emerged as one of the most common public health problems in Malaysia, particularly among Malaysian Chinese and Malays. This study aimed to observe the spectrum of mutations found in Kelantan Malay beta-thalassaemia major patients...
Topics
- Child
- Ethnicity
- Humans
- Malaysia
- Mutation
- Reverse Transcriptase Polymerase Chain Reaction
- beta-Globins
- beta-Thalassemia