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Article

Inter-laboratory comparison of DNA preservation in archival paraffin-embedded human brain tissue from participating centres on four continents.

Neurogenetics - 1 Jul 2001

Kösel S, Grasbon-Frodl E M, Arima K, Chimelli L, Hahn M, Hashizume Y, Hulette C, Ikeda K, Jacobsen P F, Jones M, Kobayashi M, Love S, Mizutani T, Rosemberg S, Sasaki A, Smith T W, Takahashi H, Vortmeyer A O, Graeber M B

Abstract excerpt

DNA extracted from formalin-fixed and paraffin-embedded brain tissue is known to contain as yet ill-characterized inhibitors of the PCR process. As part of a project that aims to clarify the role of mitochondrial DNA sequence variation in human neurodegenerative diseases using DNA from various ethnic backgrounds, we have investigated factors that influence the preservation of archival DNA and its suitability for...

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PMID: 11523568
DOI: 10.1007/s100480100114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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