Single- and multi-locus association tests incorporating phenotype heterogeneity.

Abstract excerpt

Taking disease subtypes into account when testing for an association between genetic factors and disease risk may help to identify specific aetiologic pathways. One way to assess a genetic association, whilst accounting for heterogeneity, is to use polytomous regression. This approach only allows heterogeneity to be considered in terms of a single categorical variable. In this article, we describe an alternative...

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