A multilocus technique for risk evaluation of patients with neuroblastoma.

doi:10.1158/1078-0432.CCR-10-0830

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Article

A multilocus technique for risk evaluation of patients with neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2011

Ambros Inge M, Brunner Bettina, Aigner Gerhard, Bedwell Clare, Beiske Klaus, Bénard Jean, Bown Nick, Combaret Valerie, Couturier Jerome, Defferrari Raffaella, Gross Nicole, Jeison Marta, Lunec John, Marques Barbara, Martinsson Tommy, Mazzocco Katia, Noguera Rosa, Schleiermacher Gudrun, Speleman Frank, Stallings Ray, Tonini Gian Paolo, Tweddle Deborah A, Valent Alexander, Vicha Ales, Roy Nadine Van, Villamon Eva, Ziegler Andrea, Preuner Sandra, Drobics Mario, Ladenstein Ruth, Amann Gabriele, Schuit Robert J L, Pötschger Ulrike, Ambros Peter F

Abstract excerpt

PURPOSE: Precise and comprehensive analysis of neuroblastoma genetics is essential for accurate risk evaluation and only pangenomic/multilocus approaches fulfill the present-day requirements. We present the establishment and validation of the PCR-based multiplex ligation-dependent probe amplification (MLPA) technique for neuroblastoma. EXPERIMENTAL DESIGN: A neuroblastoma-specific MLPA kit was designed by the...

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PMID: 21325297
DOI: 10.1158/1078-0432.CCR-10-0830

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