Article
Mutation analysis of the glial cell line-derived neurotrophic factor gene in Parkinson's disease.
Experimental neurology - 1 Aug 1998
Wartiovaara K, Hytönen M, Vuori M, Paulin L, Rinne J, Sariola H
Abstract excerpt
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for nigrostriatal dopaminergic, central cholinergic, and motoneurons. GDNF also prevents the neuronal loss in experimental animal models for Parkinson's disease (PD). We have now investigated the GDNF gene for possible mutations in a group of nonfamilial PD and other patients. By cleavase fragment length polymorphism (CFLP) analysis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.