Mutation analysis of the glial cell line-derived neurotrophic factor gene in Parkinson's disease.

doi:10.1006/exnr.1998.6857

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Article

Mutation analysis of the glial cell line-derived neurotrophic factor gene in Parkinson's disease.

Experimental neurology - 1 Aug 1998

Wartiovaara K, Hytönen M, Vuori M, Paulin L, Rinne J, Sariola H

Abstract excerpt

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for nigrostriatal dopaminergic, central cholinergic, and motoneurons. GDNF also prevents the neuronal loss in experimental animal models for Parkinson's disease (PD). We have now investigated the GDNF gene for possible...

Topics

Alzheimer Disease
Case-Control Studies
Glial Cell Line-Derived Neurotrophic Factor
Humans
Mutation
Nerve Growth Factors
Nerve Tissue Proteins
Neuroprotective Agents
Parkinson Disease
Polymerase Chain Reaction

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