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Article

Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.

Blood - 17 Mar 2011

Maetzig Tobias, Brugman Martijn H, Bartels Stefan, Heinz Niels, Kustikova Olga S, Modlich Ute, Li Zhixiong, Galla Melanie, Schiedlmeier Bernhard, Schambach Axel, Baum Christopher

Abstract excerpt

Gene therapy has proven its potential to cure diseases of the hematopoietic system. However, severe adverse events observed in clinical trials have demanded improved gene-transfer conditions. Whereas progress has been made to reduce the genotoxicity of integrating gene vectors, the role of pretra...

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Identifiers

PMID: 21248062
DOI: 10.1182/blood-2010-08-303222

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TPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21248062-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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