Article
Multiplexed genotyping of beta globin mutations with MALDI-TOF mass spectrometry.
Clinica chimica acta; international journal of clinical chemistry - 12 May 2011
Looi Mee-Lee, Sivalingam Mageswary, Husin Nor Diana, Radin Fara Zela Mohd, Isa Raihana Mohamed, Zakaria Syed Zulkifli Syed, Hussin Noor Hamidah, Alias Hamidah, Latiff Zarina Abd, Ibrahim Hishamshah, Jamal Rahman
Abstract excerpt
BACKGROUND: Beta thalassemia represents a great heterogeneity as over 300 mutations have been identified and each population at-risk has its own spectrum of mutations. Molecular characterization with high accuracy, sensitivity and economics is required for population screening and genetic counseling. METHODS: We used the MALDI-TOF mass spectrometry (MS) platform to develop novel multiplex assays for comprehensive...
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