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Article

Why do young women smoke? VII COMT as a risk modifying gene for Nicotine dependence - role of gene-gene interaction, personality, and environmental factors.

Human psychopharmacology - 1 Nov 2010

Greenbaum Lior, Kanyas Kyra Sarner, Rigbi Amihai, Alkelai Anna, Kohn Yoav, Lerer Bernard

Abstract excerpt

OBJECTIVES: Catechol-O-methyltransferase (COMT) may be a risk modifying gene for Nicotine dependence (ND) rather than a direct susceptibility gene for this phenotype. Brain nicotinic cholinergic receptors modulate dopaminergic transmission, and several variants within the neighboring CHRNA5-CHRNA3 genes have been associated with ND. Therefore, it is biologically reasonable to study the interactive contribution of...

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Source

Identifiers

PMID: 21312287
DOI: 10.1002/hup.1149

Genes

COMT
CHRNA3
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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