Neural regulation of intestinal smooth muscle growth in vitro.

doi:10.1152/ajpgi.2000.279.3.G511

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Article

Neural regulation of intestinal smooth muscle growth in vitro.

American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2000

Blennerhassett M G, Lourenssen S

Abstract excerpt

The loss of intrinsic neurons is an early event in inflammation of the rat intestine that precedes the growth of intestinal smooth muscle cells (ISMC). To study this relationship, we cocultured ISMC and myenteric plexus neurons from the rat small intestine and examined the effect of scorpion venom, a selective neurotoxin, on ISMC growth. By 5 days after neuronal ablation, ISMC number increased to 141+/-13% (n =...

Topics

Actins
Adrenergic beta-Antagonists
Animals
Atropine
Blotting, Western
Cell Differentiation
Cell Division
Cells, Cultured
Cholinergic Fibers
Colon
Ganglionic Blockers
Hexamethonium
In Vitro Techniques
Jejunum
Male
Muscle Development
Muscle Fibers, Skeletal
Muscle, Smooth

Source

Open in PubMed

Identifiers

PMID: 10960349
DOI: 10.1152/ajpgi.2000.279.3.G511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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