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Article

Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS).

Journal of autism and developmental disorders - 1 Dec 2005

Gornick M C, Addington A M, Sporn A, Gogtay N, Greenstein D, Lenane M, Gochman P, Ordonez A, Balkissoon R, Vakkalanka R, Weinberger D R, Rapoport J L, Straub R E

Abstract excerpt

Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological and cognitive performance, premorbid dysfunction and clinical follow-up were obtained. Fourteen SNPs were...

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Source

Identifiers

PMID: 16283082
DOI: 10.1007/s10803-005-0028-3

Genes

DTNBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS).PMID 16283082Read ↗

Dysbindin-1 gene contributes differentially to early- and adult-onset forms of functional psychosis.Semantic proximity Read ↗

Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.Semantic proximity Read ↗

Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?Semantic proximity Read ↗

Comprehensive analysis of tagging sequence variants in DTNBP1 shows no association with schizophrenia or with its composite neurocognitive endophenotypes.Semantic proximity Read ↗

DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the gene.Semantic proximity Read ↗

A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry.Semantic proximity Read ↗

Analysis of HapMap tag-SNPs in dysbindin (DTNBP1) reveals evidence of consistent association with schizophrenia.Semantic proximity Read ↗

Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients.Semantic proximity Read ↗

Association study of DTNBP1 with schizophrenia in a US sample.Semantic proximity Read ↗

The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease.Semantic proximity Read ↗

Schizophrenia-associated gene dysbindin-1 and tardive dyskinesia.Semantic proximity Read ↗

Untranslated region haplotype in dysbindin gene: analysis in schizophrenia.Semantic proximity Read ↗

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