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Article

Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD.

PloS one - 3 Feb 2011

Young Robert P, Hopkins Raewyn J, Whittington Chris F, Hay Bryan A, Epton Michael J, Gamble Gregory D

Abstract excerpt

Epidemiological studies show that approximately 20-30% of chronic smokers develop chronic obstructive pulmonary disease (COPD) while 10-15% develop lung cancer. COPD pre-exists lung cancer in 50-90% of cases and has a heritability of 40-77%, much greater than for lung cancer with heritability of 15-25%. These data suggest that smokers susceptible to COPD may also be susceptible to lung cancer. This study examines...

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Identifiers

PMID: 21304900
DOI: 10.1371/journal.pone.0016476
PMCID: PMC3033394

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FEV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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